It is probably best just to point you to the Fedora Wiki
FC6 page for all the latest and greatest news about Fedora Core 6.
Here is a short list of what is new:
• Installer multi repo support. iSCSI, firewire and USB storage installation
• New DNA theme
• Dejavu LGC font on locales where it shows a good difference like Greek language.
• GCJ web plugin playing an interesting applet
• Compiz eye candy + planned integration for switching the window manager easily.
• Pupplet - Yum based updater applet
• Brand new system-config-printer
• Xen virt-manager user interface
• Eclipse 3.2
• Alacarte menu editor
• Orca Screenreader
• setroubleshoot - SELinux graphical trouble shooting tool.
• Dogtail - desktop automation and testing framework
• GNUCash 2.0
• Fedora on Intel Macs